RegisterLogin

Iproniazid

CAT: 804-HY-B0886A-01Size: 100 mgDry Ice: NoHazardous: No
100 mgSelected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Iproniazid is an orally active, irreversible, non-selective monoamine oxidase (MAO) inhibitor. Iproniazid inhibits MAO activity and enhances Rotenone (HY-B1756) -induced Apoptosis. Iproniazid modulates neurotransmitter levels, affects neuronal function, induces hepatic necrosis, and interferes with the endocrine system. Iproniazid can be used in the research of depression, Parkinson's disease, and hepatotoxicity[1][2][3][4][5][6][7].
CAS Number
[54-92-2]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Monoamine Oxidase
Type
Reference compound
Related Pathways
Apoptosis; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Endocrinology; Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/iproniazid.html
Concentration
10mM
Purity
99.91
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL
Smiles
O=C(C1=CC=NC=C1)NNC(C)C
Molecular Formula
C9H13N3O
Molecular Weight
179.22
Precautions
H302, H315, H319, H335
References & Citations
[1]Fagervall I, et al. Inhibition of monoamine oxidase in monoaminergic neurones in the rat brain by irreversible inhibitors. Biochemical pharmacology 35 (8) : 1381–1387|[2]Watabe M, et al. Mitochondrial complex I inhibitor rotenone-elicited dopamine redistribution from vesicles to cytosol in human dopaminergic SH-SY5Y cells. J Pharmacol Exp Ther. 2007 Nov;323 (2) :499-507. |[3]Dodson AM, et al. Serotonin uptake and metabolism by cultured guinea pig airway smooth muscle cells. Pulm Pharmacol Ther. 2004;17 (1) :19-25. |[4]De Oliveira LF, et al. Effects of 5-hydroxytryptophan, iproniazid and p-chlorophenylalanine on lidocaine seizure threshold of mice. Eur J Pharmacol. 1974 Nov;29 (1) :5-9.|[5]Nelson SD, et al. Hepatotoxicity and metabolism of iproniazid and isopropylhydrazine. J Pharmacol Exp Ther. 1978 Sep;206 (3) :574-85.|[6]SETNIKAR I V O, et al. Retardation of sexual development in female rats due to iproniazid treatment. Endocrinology, 1960, 67 (4) : 511-520.|[7]Huang J T, et al. The effect of pretreatment with iproniazid on the behavioral activities of β-phenylethylamine in rats. Psychopharmacologia, 1974, 35 (1) : 77-81.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Launched

Related Products

CatalogName

Alternative Products

CatalogName
014945Iproniazid
MBS3842340-01Iproniazid
sc-488321Iproniazid
TRC-I746500-5GIproniazid
584442Iproniazid
T20085Iproniazid
MBS5756326Iproniazid
MBS6104241-01Iproniazid
TRC-I746500-500MGIproniazid
OR916950-01Iproniazid

Popular Products