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Isoxanthohumol

CAT: 0804-HY-N2584A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N2584A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Isoxanthohumol is an orally active flavonoid compound. Isoxanthohumol has biological activities such as anti-tumor, anti-inflammatory, antioxidant, antiviral, antifungal, and inhibition of adipogenesis. Isoxanthohumol can induce apoptosis, autophagy, and migration of tumor cells. Isoxanthohumol is active against viruses such as HSV, BVDV, CMV, and Rhino. Isoxanthohumol can be used for the research of tumors, metabolic, and inflammatory diseases[1][2][3][4][5].
CAS Number
521-48-2
UNSPSC
12352005
Target
Apoptosis; Autophagy; CMV; Fungal; HSV; Integrin; Reactive Oxygen Species (ROS) ; S100 Protein
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Autophagy; Cytoskeleton; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/isoxanthohumol.html
Concentration
10mM
Purity
99.91
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OC1=CC(OC)=C2C(CC(OC2=C1C/C=C(C)\C)C3=CC=C(C=C3)O)=O
Molecular Formula
C21H22O5
Molecular Weight
354.40
References & Citations
[1]Żołnierczyk AK, et al. Isoxanthohumol--Biologically active hop flavonoid. Fitoterapia. 2015 Jun;103:71-82.|[2]Krajnović T, et al. The hop-derived prenylflavonoid isoxanthohumol inhibits the formation of lung metastasis in B16-F10 murine melanoma model. Food Chem Toxicol. 2019 Jul;129:257-268.|[3]Yan YF, et al. The Antifungal Mechanism of Isoxanthohumol from Humulus lupulus Linn. Int J Mol Sci. 2021 Oct 7;22 (19) :10853.|[4]Yang JY, et al. Effect of xanthohumol and isoxanthohumol on 3T3-L1 cell apoptosis and adipogenesis. Apoptosis. 2007 Nov;12 (11) :1953-63.|[5]Yang YN, et al. Therapeutic effects and mechanisms of isoxanthohumol on DSS-induced colitis: regulating T cell development, restoring gut microbiota, and improving metabolic disorders. Inflammopharmacology. 2024 Jun;32 (3) :1983-1998.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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