Haloperidol

CAT: 0804-HY-14538-01Size: 100 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-14538-01Size:100 mg

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Description

Haloperidol is a potent dopamine D2 receptor antagonist, widely used as an antipsychotic.

CAS Number

52-86-8

UNSPSC

12352005

Hazard Statement

H301, H315, H317, H319, H335, H361

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Haloperidol.html

Purity

99.73

Solubility

DMSO : 40 mg/mL (ultrasonic)

Smiles

ClC(C=C1)=CC=C1C2(O)CCN(CCCC(C3=CC=C(F)C=C3)=O)CC2

Molecular Formula

C21H23ClFNO2

Molecular Weight

375.86

Precautions

H301, H315, H317, H319, H335, H361

References & Citations

[1]Furuta Y, et al. Effects of enzyme inhibitors of catecholamine metabolism and of haloperidol on the pancreatic secretion induced by L-DOPA and by dopamine in dogs. Br J Pharmacol. 1973 Jan;47 (1) :77-84|[2]Shah NS, et al. Effects of chlorpromazine and haloperidol on the disposition of mescaline-14C in mice. J Pharmacol Exp Ther. 1973 Aug;186 (2) :297-304|[3]Lei K, et al. Investigation of the synergistic effects of haloperidol combined with Calculus Bovis Sativus in treating MK-801-induced schizophrenia in rats. Exp Anim. 2018 May 10;67 (2) :163-173. |[4]Guzen FP, et al. Haloperidol-Induced Preclinical Tardive Dyskinesia Model in Rats. Curr Protoc Neurosci. 2019 Jun;88 (1) :e68.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

D2 Receptor

Citation 01

ACS Omega. 2020 Nov 15;5 (46) :29935-29942.|ACS Omega. 2025 Oct 17;10 (42) :50208-50217.|Adv Sci (Weinh) . 2025 Sep;12 (33) :e02276.|BMC Endocr Disord. 2021 Nov 23;21 (1) :235.|Br J Pharmacol. 2021 Sep;178 (17) :3570-3586.|Cell Rep Methods. 2023 Oct 23;3 (10) :100599.|Cell. 2023 Nov 22;186 (24) :5347-5362.e24.|Clin Exp Pharmacol Physiol. 2021 Mar;48 (3) :370-380.|Environ Sci Technol. 2023 Sep 26;57 (38) :14162-14172.|Eur J Integr Med. 2021, 101322.|Eur J Pharmacol. 2023 Dec 15:961:176174.|Eur J Pharmacol. 2023 May 5:946:175647.|J Ethnopharmacol. 2021 Jun 12:273:113994.|Oncogenesis. 2025 Aug 21;14 (1) :31.|Phytomedicine. 2025 Jun:141:156707.|PLoS Negl Trop Dis. 2019 Aug 20;13 (8) :e0007681. |University of South Carolina. 2025.|University of Zurich. 2025.|Behav Brain Res. 2022 Mar 26:422:113759.|EMBO Rep. 2022 Feb 3;23 (3) :e53191.

Chemical Information

Haloperidol

Haloperidol can cause developmental toxicity and female reproductive toxicity according to state or federal government labeling requirements.

CAS Number	52-86-8
PubChem CID	3559
IUPAC Name	4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one
Molecular Formula	C21H23ClFNO2
Molecular Weight	375.9
XLogP	3.2
Topological Polar Surface Area	40.5
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	6
Heavy Atom Count	26
Formal Charge	0
Complexity	451

SMILES

C1CN(CCC1(C2=CC=C(C=C2)Cl)O)CCCC(=O)C3=CC=C(C=C3)F

InChI

InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2

InChIKey

LNEPOXFFQSENCJ-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 52-86-8

CID: 3559

Formula: C21H23ClFNO2

MW: 375.9

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	375.9
XLogP3	3.2
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	6
Exact Mass	375.1401348
Monoisotopic Mass	375.1401348
Topological Polar Surface Area	40.5 Å²
Heavy Atom Count	26
Formal Charge	0
Complexity	451
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
B2099-500	Haloperidol

Haloperidol

Chemical Information

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