Glyphosate

CAT: 0804-HY-B0863-01Size: 500 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0863-01Size:500 mg
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Description
Glyphosate, a non-selective systemic biocide with broad-spectrum activity, is an herbicidal derivative of the amino acid glycine. Glyphosate inhibits the enzymatic activity of the 5-endopyruvylshikimate 3-phosphate synthase (EPSPS) in the shikimic acid pathway, preventing the synthesis of the aromatic amino acids tyrosine, phenylalanine, and tryptophan. Glyphosate induces oxidative stress, neuroinflammation, and mitochondrial dysfunction, processes that lead to neuronal death by autophagia, necrosis, or apoptosis, as well as the appearance of behavioral and motor disorders[1][2][3].
CAS Number
[1071-83-6]
UNSPSC
12352211
Hazard Statement
H312, H318, H411
Target
Apoptosis; Autophagy; Necroptosis
Type
Reference compound
Related Pathways
Apoptosis; Autophagy
Applications
Cancer-programmed cell death
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/glyphosate.html
Purity
98.00
Solubility
H2O : 13.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(O)CNCP(O)(O)=O
Molecular Formula
C3H8NO5P
Molecular Weight
169.07
Precautions
H312, H318, H411
References & Citations
[1]Greim H, et al. Evaluation of carcinogenic potential of the herbicide glyphosate, drawing on tumor incidence data from fourteen chronic/carcinogenicity rodent studies. Crit Rev Toxicol. 2015;45 (3) :185-208.|[2]Zhang JW, et al The toxic effects and possible mechanisms of glyphosate on mouse oocytes. Chemosphere. 2019 Dec;237:124435.|[3]Carmen Costas-Ferreira, et al. Toxic Effects of Glyphosate on the Nervous System: A Systematic Review. Int J Mol Sci. 2022 Apr 21;23 (9) :4605.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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