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Skatole

CAT: 0804-HY-W007355-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0804-HY-W007355-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Skatole (3-methylindole) is a heterocyclic compound naturally found in the feces of vertebrates and can be found in certain plants. Skatole can be produced by intestinal bacteria, inducing apoptosis of intestinal epithelial cells through activating aryl hydrocarbon receptors (AhR) and p38. Skatole has been used in specific products of the perfume industry or as a flavor additive in ice cream[1][2].
CAS Number
83-34-1
Product Name Alternative
3-Methylindole; 3-Methyl-1H-indole
UNSPSC
12352005
Hazard Statement
H411
Target
Apoptosis; Aryl Hydrocarbon Receptor; Endogenous Metabolite; p38 MAPK
Type
Natural Products
Related Pathways
Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/Skatole.html
Purity
99.99
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=CNC2=CC=CC=C12
Molecular Formula
C9H9N
Molecular Weight
131.18
Precautions
H411
References & Citations
[1]Kurata K, et al. Skatole regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38. Biochem Biophys Res Commun. 2019 Mar 19;510 (4) :649-655.|[2]Zgarbová E, et al. Skatole: A thin red line between its benefits and toxicity. Biochimie. 2023 May;208:1-12.|[3]Li RL, et al. Irisin attenuates vascular remodeling in hypertensive mice induced by Ang II by suppressing Ca2+-dependent endoplasmic reticulum stress in VSMCs. Int J Biol Sci. 2024 Jan 1;20 (2) :680-700.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite; Microbial Metabolite; p38 MAPK

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