BAFF (Animal Free)

CAT: 0209-100-002-L250-AFSize: 250 μgDry Ice: NoHazardous: No

1 / 1

CAT#:0209-100-002-L250-AFSize:250 μg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

B-cell-activating factor (BAFF), also known as BlyS and TNFSF13B, is a member of the tumor necrosis factor family of ligands. BAFF is a type II membrane protein and serves as a ligand for TNF receptors TACI (TNFRSF13B), BCMA (TNFRSF17) and BAFF-R (TNFRSF13C) . These receptors are prominent factors in B cell differentiation, homeostasis, selection and survival. Thus, BAFF functions as a potent B cell activator and regulates the proliferation and differentiation of B cells and may contribute to survival of autoantibody-producing B cells. BAFF is expressed in macrophages, monocytes, dendritic cells and T cells. The human BAFF gene codes for a 285 amino acid peptide with a 46 amino acid cytoplasmic domain, a 21 amino acid transmembrane domain and a 21 amino acid transmembrane domain. Recombinant Human Soluble BAFF (Animal Free) consists of 152 amino acid residues, representing the TNF-like portion of the extracellular domain of BAFF and has a molecular weight of 17.0 kDa.

Synonyms

B lymphocyte stimulator, BLYS, B-cell-activating factor, Dendritic cell-derived TNF-like molecule, DTL, Tumor necrosis factor ligand superfamily member 13B, TNFSF13B, CD257, TALL1, THANK, ZTNF4, TALL-1, TNFSF20, TNLG7A

NCBI Gene ID

10673

UniProt

Q9Y275

Accession Number

NP_006564.1

Accession Number mRNA

NM_006573.4

Chromosomal Location

13q32-q34

Reactivity

Human

Sequence

AVQGPEETVTQDCLQLIADSETPTIQKGSYTFVPWLLSFKRGSALEEKENKILVKETGYFFIYGQVLYTKTYAMGHLIQRKKVHVFGDELSLVTLFRCIQNMPETLPNNSCYSAGIAKLEEGDELQLAIPRENAQISLDGDVTFFGALKLL

Detection Range

Determined by dose-dependent NFκB activation in HEK293 BCMA–NFκB reporter cells. The expected ED50 for this effect is 100-200ng/mL.

Endotoxin

< 0.01 ng/μg of protein (< 0.1 EU/μg)

Purity

≥ 95% by SDS-PAGE gel and HPLC analyses.

Length

152

Molecular Weight

17.0 kDa

Formulation

Lyophilized

Host or Source

E. coli

Species

Human

UniProtKB · Q9Y275

Tumor necrosis factor ligand superfamily member 13B

TN13B_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q9Y275
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: TNFSF13B
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: E0ADT7, Q6FHD6, Q7Z5J2

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneMembraneSecreted

PTM

Cleavage on pair of basic residuesDisulfide bondGlycoprotein

Molecular function

Cytokine

Biological process

Immunity

Domain

Signal-anchorTransmembraneTransmembrane helix

Related Products

Catalog	Name
M10-028S-AF	Leptin (animal-free)
R20-047-L1000-AF	GDNF (Animal Free)
M10-116-L1000-AF	GDNF (Animal Free)
100-030-L500-AF	GDNF (Animal Free)
100-030-L50-AF	GDNF (Animal Free)
100-336-L250-AF	Epiregulin (Animal Free)
100-409-L500-AF	Enterokinase (Animal Free)
100-409-L100-AF	Enterokinase (Animal Free)
R20-072-L1000-AF	EGF (Animal Free)
R20-001-L500-AF	CNTF (Animal Free)

Alternative Products

Catalog	Name
MBS692867-01	Human BAFF (Animal Free)
40-760	BAFF Recombinant Protein (Animal Free)
HY-P700017AF-01	Animal-Free BAFF/TNFSF13B, Human (His)
HY-P700161AF-01	Animal-Free BAFF/TNFSF13B, Mouse (His)
PRP1178-01	Mouse BAFF Protein, His tag (Animal-Free)
MBS8432819-01	Human, Mouse BAFF Recombinant Protein (Animal Free) Lyophilized
C-CYP202-500ug	Recombinant Mouse BAFF / B-Cell Activating Factor, Animal Free & Carrier Free
C-CYP220-100ug	Recombinant Human BAFF / B-Cell Activating Factor, Animal Free & Carrier Free
IHUMSBAFFRAFLY5UG	Human, Mouse BAFF Recombinant Protein (Animal Free) Lyophilized 5UG
GTR18895461-01	Recombinant BAFF (B-cell activating factor), Human, Animal-Free