Apomorphine HCl Hydrate

• Background:

  Archetypal dopamine pan-receptor agonist. Displays anti-Parkinsons activity in vivo (1,2). Protects against MPTP-induced neurotoxicity in a mouse model (3). In clinical use for Parkinson’s disease (4,5).

• Description:

  Dopamine Agonist

• Product Name Alternative:

  Hemihydrate; R-(-)-6ab-aporphine-10,11-diol, hydrochloride; (R)-5,6,6a,7-Tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diol, hydrochloride

• CAS Number:

  41372-20-7

• UNSPSC:

  41116105

• Source:

  Synthetic

• Purity:

  >98% (TLC); NMR (Conforms)

• Weight:

  0.005

• Format:

  Gray Powder

• Solubility:

  May be dissolved in water (20 mg/ml)

• Molecular Formula:

  C17H17NO2 • HCl ½H2O

• Molecular Weight:

  312.8

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Merck Index 14:746 2.Millan M.J., et al. (2002) J. Pharmacol. Exp. Ther. 303:791. 3. Grunblatt E., et al. (1999) Mov. Disord. 1999 14:612. 4. Auffret M., et al.( 2017) J. Neurol. Sci. 372:279. 5. Jenner P.and R Katzenschlager ( 2016) Parkinsonism. Relat. Disord. 33 Suppl 1:S13.