MANF

CAT: 0209-100-136-L500Size: 500 μgDry Ice: NoHazardous: No

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CAT#:0209-100-136-L500Size:500 μg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

MANF is a secreted neurotrophic factor that is expressed in brain, neuronal and certain non-neuronal tissues. It has been shown to promote survival, growth and function of dopamine specific neurons. MANF and its structural homolog CDNF, each contain an N-terminal saposin-like lipid binding domain, and a carboxyl-terminal domain, which is not homologous to previously characterized protein structures. MANF and CDNF can prevent 6-OHDA induced degeneration of dopaminergic neurons by triggering survival pathways in a rat experimental model of Parkinson disease. Recombinant human MANF is an 18.1 kDa protein consisting of 158 amino acids including 8 cysteine residues.

Synonyms

MANF; ARP; ARMET

NCBI Gene ID

7873

UniProt

P55145

Accession Number

NP_006001.3

Accession Number mRNA

NM_006010.4

Chromosomal Location

3p21.1

Reactivity

Human

Sequence

LRPGDCEVCI SYLGRFYQDL KDRDVTFSPA TIENELIKFC REARGKENRL CYYIGATDDA ATKIINEVSK PLAHHIPVEK ICEKLKKKDS QICELKYDKQ IDLSTVDLKK LRVKELKKIL DDWGETCKGC AEKSDYIRKI NELMPKYAPK AASARTDL

Detection Range

Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 for this effect is 15-25 μg/ml.

Endotoxin

< 0.1 ng/μg of protein (< 1 EU/μg)

Purity

> 98% by SDS-PAGE & HPLC analyses

Length

158

Molecular Weight

18.1 kDa

Formulation

Lyophilized

Host or Source

E. coli

Species

Human

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cyt-141-01	MANF
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391292	MANF discontinued
MBS7128420-01	MANF Antibody
MBS692051-01	Human MANF
OM297634-01	MANF Rat
4347P	MANF Peptide
GTR18984859-01	MANF Protein

MANF

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