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Ligelizumab

CAT: 0804-HY-P99300-01Size: 1 mgDry Ice: YesHazardous: No
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CAT#:0804-HY-P99300-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ligelizumab (QGE 031) is a humanized high-affinity anti-immunoglobulin IgE monoclonal antibody. Ligelizumab selectively inhibits the binding of IgE to the high-affinity receptor FcεRI, while the inhibitory effect on the low-affinity receptor CD23 is weak. Ligelizumab can inhibit the activation of effector cells such as mast cells and Basophil, while reducing the production of IgE by B cells, and restoring the IFN-α production and regulatory T cell (Treg) induction function of plasmacytoid dendritic cells (pDC) . Ligelizumab can be used in the study of allergic diseases (such as chronic spontaneous urticaria, allergic asthma) [1][2].
CAS Number
1322627-61-1
Product Name Alternative
QGE 031; Anti-IGHE Recombinant Antibody
UNSPSC
12352203
Target
Fc Receptor (FcR)
Type
Inhibitory Antibodies
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ligelizumab.html
Purity
99.85
Solubility
H2O
Smiles
[Ligelizumab]
Molecular Weight
(146.32 kDa)
References & Citations
[1]Gasser P, et al. The mechanistic and functional profile of the therapeutic anti-IgE antibody ligelizumab differs from omalizumab. Nat Commun. 2020 Jan 8;11 (1) :165.|[2]Benito-Villalvilla C, et al. Ligelizumab impairs IgE-binding to plasmacytoid dendritic cells more potently than omalizumab and restores IFN-α production and FOXP3+ Treg generation. Allergy. 2023 Apr;78 (4) :1060-1072.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Phase 3

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