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CC260

CAT: 0804-HY-139188-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-139188-02Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CC260 is a selective PI5P4Kα and PI5P4Kβ inhibitor with Kis of 40 nM and 30 nM, respectively. CC260 does not inhibit or weakly inhibits other protein kinases, such as Plk1 and RSK2. CC260 can be used for cell energy metabolism, diabetes and cancer research[1].
CAS Number
2411088-26-9
UNSPSC
12352005
Target
PI5P4K
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/cc260.html
Purity
99.45
Solubility
DMSO : 160 mg/mL (ultrasonic)
Smiles
CN(C1=O)C(C(N(C2CCCC2)[C@@H]1CC3CCCC3)=N4)=CN=C4NC5=CC(Cl)=C(C(Cl)=C5)O
Molecular Formula
C24H29Cl2N5O2
Molecular Weight
490.43
References & Citations
[1]Song Chen, et al. Pharmacological inhibition of PI5P4Kα/β disrupts cell energy metabolism and selectively kills p53-null tumor cells. Proc Natl Acad Sci U S A. 2021 May 25;118 (21) :e2002486118.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

CID 146347307
CAS Number2411088-26-9
PubChem CID146347307
IUPAC Name(7R)-8-cyclopentyl-7-(cyclopentylmethyl)-2-(3,5-dichloro-4-hydroxyanilino)-5-methyl-7H-pteridin-6-one
Molecular FormulaC24H29Cl2N5O2
Molecular Weight490.4
XLogP6.5
Topological Polar Surface Area81.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Heavy Atom Count33
Formal Charge0
Complexity678
SMILES
CN1C2=CN=C(N=C2N([C@@H](C1=O)CC3CCCC3)C4CCCC4)NC5=CC(=C(C(=C5)Cl)O)Cl
InChI
InChI=1S/C24H29Cl2N5O2/c1-30-20-13-27-24(28-15-11-17(25)21(32)18(26)12-15)29-22(20)31(16-8-4-5-9-16)19(23(30)33)10-14-6-2-3-7-14/h11-14,16,19,32H,2-10H2,1H3,(H,27,28,29)/t19-/m1/s1
InChIKey
AEZJZTFWCDAUDF-LJQANCHMSA-N
Chemical Structure
2D Structure
2D structure of CID 146347307
CAS: 2411088-26-9
CID: 146347307
Formula: C24H29Cl2N5O2
MW: 490.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight490.4
XLogP36.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Exact Mass489.1698306
Monoisotopic Mass489.1698306
Topological Polar Surface Area81.6 Ų
Heavy Atom Count33
Formal Charge0
Complexity678
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
BA8275-1CC260

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