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Spiroxatrine

CAT: 0804-HY-12706-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12706-01Size:5 mg
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Description
Spiroxatrine (R 5188) is a selective, dual antagonist of 5-HT1α and α2-adrenergic, with the Ki values of 3.94, 224000, 118.5 nM for 5-HT1α, 5-HT1β and 5-HT2, respectively. Spiroxatrine (R 5188) has a sedative effect[1][2][3][4].
CAS Number
1054-88-2
Product Name Alternative
R 5188
UNSPSC
12352005
Target
5-HT Receptor; Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/spiroxatrine.html
Purity
99.25
Solubility
DMSO : 1.92 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1NCN(C2=CC=CC=C2)C13CCN(CC4OC5=CC=CC=C5OC4)CC3
Molecular Formula
C22H25N3O3
Molecular Weight
379.45
References & Citations
[1]D L Nelson, et al. Spiroxatrine: a selective serotonin1A receptor antagonist. Eur J Pharmacol. 1986 May 13;124 (1-2) :207-8.|[2]Linda Cleary, et al. Investigation of neurotransmission in vas deferens from alpha (2A/D) -adrenoceptor knockout mice. Br J Pharmacol. 2002 Jul;136 (6) :857-64.|[3]Z-Y Liu, et al. Involvement of 5-hydroxytryptamine (1A) receptors in the descending anti-nociceptive pathway from periaqueductal gray to the spinal dorsal horn in intact rats, rats with nerve injury and rats with inflammation. Neuroscience. 2002;112 (2) :399-407.|[4]W J McBride, et al. Spiroxatrine augments fluoxetine-induced reduction of ethanol intake by the P line of rats. Pharmacol Biochem Behav. 1989 Oct;34 (2) :381-6.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MLAG-3; α adrenergic receptor; α-1 microglobulin

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