Interleukin-17A (IL-17A, Human, Recombinant)

• Description:

  Interleukin-17A (IL-17A)_x000D_ Catalog number: B2010266_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Volume/Weight: 10 ug_x000D_ pH: n/a_x000D_ Supplied as: Reconstitute before use_x000D_ Appearance: Solid_x000D_ Applications: highly pure recombinant human Interleukin 17A (expressed in CHO cells). IL-17A is involved in innate and acquired immunity through the accumulation of polymorphonuclear neutrophil leukocytes._x000D_ Storage: -20C_x000D_ Keywords: rHuIL-17A, His; CTLA-8; IL-17A_x000D_ Grade: Biotechnology grade. All components are highly pure (minimum 99%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered on a 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Lee JS, Tato CM, Joyce-Shaikh B, Gulen MF, Cayatte C, Chen Y, Blumenschein_x000D_ WM, Judo M, Ayanoglu G, McClanahan TK, Li X, Cua DJ. Interleukin-23-Independent_x000D_ IL-17 Production Regulates Intestinal Epithelial Permeability. Immunity. 2015_x000D_ Oct 20;43(4):727-38._x000D_ _x000D_ 2: Frangou E, Chrysanthopoulou A, Mitsios A, Kambas K, Arelaki S, Angelidou I,_x000D_ Arampatzioglou A, Gakiopoulou H, Bertsias GK, Verginis P, Ritis K, Boumpas DT._x000D_ REDD1/autophagy pathway promotes thromboinflammation and fibrosis in human_x000D_ systemic lupus erythematosus (SLE) through NETs decorated with tissue factor_x000D_ (TF) and interleukin-17A (IL-17A). Ann Rheum Dis. 2019 Feb;78(2):238-248._x000D_ PMC6352428._x000D_ _x000D_ 3: Glatt S, Baeten D, Baker T, Griffiths M, Ionescu L, Lawson ADG, Maroof A,_x000D_ Oliver R, Popa S, Strimenopoulou F, Vajjah P, Watling MIL, Yeremenko N, Miossec_x000D_ P, Shaw S. Dual IL-17A and IL-17F neutralisation by bimekizumab in psoriatic_x000D_ arthritis: evidence from preclinical experiments and a randomised placebo-_x000D_ controlled clinical trial that IL-17F contributes to human chronic tissue_x000D_ inflammation. Ann Rheum Dis. 2018 Apr;77(4):523-532._x000D_ _x000D_ 4: Brembilla NC, Senra L, Boehncke WH. The IL-17 Family of Cytokines in_x000D_ Psoriasis: IL-17A and Beyond. Front Immunol. 2018 Aug 2;9:1682._x000D_ _x000D_ 5: Kolbinger F, Huppertz C, Mir A, Padova FD. IL-17A and Multiple Sclerosis:_x000D_ Signaling Pathways, Producing Cells and Target Cells in the Central Nervous_x000D_ System. Curr Drug Targets. 2016;17(16):1882-1893._x000D_ _x000D_ 6: Blauvelt A, Chiricozzi A. The Immunologic Role of IL-17 in Psoriasis and_x000D_ Psoriatic Arthritis Pathogenesis. Clin Rev Allergy Immunol. 2018_x000D_ Dec;55(3):379-390._x000D_ _x000D_ 7: Ruiz de Morales JMG, Puig L, Daudén E, Cañete JD, Pablos JL, Martín AO,_x000D_ Juanatey CG, Adán A, Montalbán X, Borruel N, Ortí G, Holgado-Martín E, García-_x000D_ Vidal C, Vizcaya-Morales C, Martín-Vázquez V, González-Gay MÁ. Critical role of_x000D_ interleukin (IL)-17 in inflammatory and immune disorders: An updated review of_x000D_ the evidence focusing in controversies. Autoimmun Rev. 2020 Jan;19(1):102429._x000D_ _x000D_ 8: Goepfert A, Lehmann S, Wirth E, Rondeau JM. The human IL-17A/F heterodimer: a_x000D_ two-faced cytokine with unique receptor recognition properties. Sci Rep. 2017_x000D_ Aug 21;7(1):8906._x000D_ _x000D_ 9: Kan J, Mishima S, Kashiwakura J, Sasaki-Sakamoto T, Seki M, Saito S, Ra C,_x000D_ Tokuhashi Y, Okayama Y. Interleukin-17A expression in human synovial mast cells_x000D_ in rheumatoid arthritis and osteoarthritis. Allergol Int. 2016 Sep;65_x000D_ Suppl:S11-6._x000D_ _x000D_ 10: McGonagle DG, McInnes IB, Kirkham BW, Sherlock J, Moots R. The role of_x000D_ IL-17A in axial spondyloarthritis and psoriatic arthritis: recent advances and_x000D_ controversies. Ann Rheum Dis. 2019 Sep;78(9):1167-1178._x000D_ _x000D_ 11: Krstic J, Obradovic H, Kukolj T, Mojsilovic S, Okic-Dordevic I, Bugarski D,_x000D_ Santibanez JF. An Overview of Interleukin-17A and Interleukin-17 Receptor A_x000D_ Structure, Interaction and Signaling. Protein Pept Lett. 2015;22(7):570-8._x000D_ _x000D_ 12: Yu C, Niu X, Du Y, Chen Y, Liu X, Xu L, Iwakura Y, Ma X, Li Y, Yao Z, Deng_x000D_ W. IL-17A promotes fatty acid uptake through the IL-17A/IL-17RA/p-STAT3/FABP4_x000D_ axis to fuel ovarian cancer growth in an adipocyte-rich microenvironment. Cancer_x000D_ Immunol Immunother. 2020 Jan;69(1):115-126._x000D_ _x000D_ 13: Kaur R, Rawat AK, Kumar S, Aadil W, Akhtar T, Narang T, Chopra D._x000D_ Association of genetic polymorphism of interleukin-17A & interleukin-17F with_x000D_ susceptibility of psoriasis. Indian J Med Res. 2018 Oct;148(4):422-426._x000D_ _x000D_ Products Related to Human Interleukin-17A (IL-17A): COVID-19

• Short Description:

  Catalog Number: B2010266 (10 ug)

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height:

  0.5

• Height :

  0.5

• CAS Number:

  9000-83-3