7,3',4'-Tri-O-methylluteolin

7,3',4'-Tri-O-methylluteolin

• CAS Number: 29080-58-8
• UNSPSC Description: 7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone), a flavonoid compound, possesses potent anti-inflammatory effects in LPS-induced macrophage cell line mediated by inhibition of release of inflammatory mediators, NO, PGE2, and pro-inflammatory cytokines. 7,3',4'-Tri-O-methylluteolin significantly induces reduction in the mRNA expressions of inducible nitric oxide synthase and cyclooxygenase-2[1].
• Target Antigen: COX; Interleukin Related; TNF Receptor
• Type: Natural Products
• Related Pathways: Apoptosis;Immunology/Inflammation
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/7-3-4-tri-o-methylluteolin.html
• Purity: 99.28
• Solubility: DMSO : 20 mg/mL (ultrasonic)
• Smiles: OC1=C2C(OC(C3=CC=C(OC)C(OC)=C3)=CC2=O)=CC(OC)=C1
• Molecular Weight: 328.32
• References & Citations: [1]Sudha, A, et al. Protective effect of 5-hydroxy-3′,4′,7-trimethoxyflavone against inflammation induced by lipopolysaccharide in RAW 264.7 macrophage: in vitro study and in silico validation. Medicinal Chemistry Research, 2016,25(9), 1754–1767.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, protect from light)
• Clinical Information: No Development Reported