IgdE protease

• Description:

  IgdE protease is a cysteine protease, which is initially isolated from Streptococcus agalactiae. IgdE protease digests monoclonal antibodies (mAbs) of the IgG1 type specifically at their upper hinge region, produces Fc/2, hinge peptide dimers, and Fab fragment. IgdE protease can be used in disulfide bonds and free thiol analysis, as it requires no reducing agents for cleavage[1].

• UNSPSC:

  12352204

• Target:

  Biochemical Assay Reagents

• Type:

  Enzyme

• Related Pathways:

  Others

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/igde-protease.html

• Smiles:

  [IgdEprotease]

• References & Citations:

  [1]Faid V, et al., Middle-up analysis of monoclonal antibodies after combined IgdE and IdeS hinge proteolysis: Investigation of free sulfhydryls. J Pharm Biomed Anal. 2018 Feb 5;149:541-546.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20°C for 2 years

• Scientific Category:

  Enzyme

• Clinical Information:

  No Development Reported

• CAS Number:

  [1892548-76-3]