IgdE protease

• Description :

  IgdE protease is a cysteine protease, which is initially isolated from Streptococcus agalactiae. IgdE protease digests monoclonal antibodies (mAbs) of the IgG1 type specifically at their upper hinge region, produces Fc/2, hinge peptide dimers, and Fab fragment. IgdE protease can be used in disulfide bonds and free thiol analysis, as it requires no reducing agents for cleavage[1].

• UNSPSC :

  12352204

• Target :

  Biochemical Assay Reagents

• Type :

  Enzyme

• Related Pathways :

  Others

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/igde-protease.html

• Smiles :

  [IgdEprotease]

• References & Citations :

  [1]Faid V, et al., Middle-up analysis of monoclonal antibodies after combined IgdE and IdeS hinge proteolysis: Investigation of free sulfhydryls. J Pharm Biomed Anal. 2018 Feb 5;149:541-546.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at -20°C for 2 years

• Scientific Category :

  Enzyme

• Clinical Information :

  No Development Reported

• CAS Number :

  [1892548-76-3]