(R)-Citalopram (oxalate) (Standard)

(R)-Citalopram (oxalate) (Standard)

• CAS Number: 219861-53-7
• UNSPSC Description: (R)-Citalopram (oxalate) (Standard) is the analytical standard of (R)-Citalopram (oxalate). This product is intended for research and analytical applications. (R)-Citalopram oxalate is an anticonvulsant, antidepressant and muscle relaxant. (R)-Citalopram oxalate is at least 20-fold weaker than S-citalopram (Escitalopram; HY-14258) as inhibitor of the 5-HT transporter (SERT). (R)-Citalopram oxalate functionally antagonises S-citalopram in vivo and in vitro. (R)-Citalopram oxalate has an effect on the association of Escitalopram with the high affinity primary site, and on its dissociation from the 5-HT transporter, via an allosteric mechanism[1].
• Target Antigen: 5-HT Receptor; Serotonin Transporter
• Type: Reference Standards
• Related Pathways: GPCR/G Protein;Neuronal Signaling
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/r-citalopram-oxalate-standard.html
• Smiles: OC(C(O)=O)=O.CN(C)CCC[C@@]1(C2=CC=C(C=C2)F)C3=CC=C(C#N)C=C3CO1
• Molecular Weight: 414.43
• References & Citations: [1]Signe í Stórustovu, et al. R-citalopram functionally antagonises escitalopram in vivo and in vitro: evidence for kinetic interaction at the serotonin transporter.  Br J Pharmacol. 2004 May;142(1):172-80.|[2]Connie Sánchez, et al.  The pharmacology of citalopram enantiomers: the antagonism by R-citalopram on the effect of S-citalopram. Basic Clin Pharmacol Toxicol. 2006 Aug;99(2):91-5.
• Shipping Conditions: Room temperature