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Recombinant Human CCL19

CAT: 0014-50184P-1Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0014-50184P-1Size:100 µg
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Description
Recombinant human CCL19 produced in E. coli
CAS Number
9000-83-3
Product Name Alternative
rHuCCL19, MIP-3beta
Gene Name
CCL19
UniProt
Q99731
Cellular Locus
Secreted.
Reactivity
Human
Target Antigen
C-C motif chemokine 19
Target
CCL19
Type
Protein
Applications
Calcium flux assay
Dilution
Centrifuge tube prior to resuspending. Recommended at 100ug/ml in sterile distilled water.
Form
Lyophilized
Function
May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to sPubMed:9498785}.
Additionnal Information
Endotoxin Level: <0.01 EU per 1ug of protein by LAL method.
Storage Conditions
12 months from date of receipt, -20°C to -70°C, as supplied. 1 month, 2°C to 8°C, under sterile conditions after reconstitution. 3 months, -20°C to -70°C, under sterile conditions after reconstitution. For in vitro investigational use only.
Specificity
CCL19
Target Background
CCL19 (also known as Macrophage Inflammatory Protein-3beta, MIP-3b, and EBI1 ligand chemokine, ELC) directs chemotaxis of dendritic cells and certain B- and T-lymphocytes, but not monocytes or granulocytes. It is constitutively expressed in thymus and lymph nodes and binds specifically to target cells expressing the receptor CCR7. As a homeostatic chemokine, its primary physiological role is thought to be in the normal recirculation and homing of lymphocytes. However, CCL19 can also be proinflammatory and is implicated in post-HIV infection responses.

UniProtKB · Q99731

C-C motif chemokine 19

CCL19_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q99731
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CCL19
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
O00697, O00736
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Biological process

ChemotaxisInflammatory response

Molecular function

Cytokine

PTM

Disulfide bond

Cellular component

Secreted

Domain

Signal

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