Recombinant Human CCL19

• Description:

  Recombinant human CCL19 produced in E. coli

• Product Name Alternative:

  rHuCCL19, MIP-3beta

• Gene Name:

  CCL19

• UniProt:

  Q99731

• Cellular Locus:

  Secreted.

• Reactivity:

  Human

• Target Antigen:

  C-C motif chemokine 19

• Target:

  CCL19

• Type:

  Protein

• Applications:

  Calcium flux assay

• Dilution:

  Centrifuge tube prior to resuspending. Recommended at 100ug/ml in sterile distilled water.

• Form:

  Lyophilized

• Function:

  May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to sPubMed:9498785}.

• Additionnal Information:

  Endotoxin Level: <0.01 EU per 1ug of protein by LAL method.

• Storage Conditions:

  12 months from date of receipt, -20°C to -70°C, as supplied. 1 month, 2°C to 8°C, under sterile conditions after reconstitution. 3 months, -20°C to -70°C, under sterile conditions after reconstitution. For in vitro investigational use only.

• Specificity:

  CCL19

• Target Background:

  CCL19 (also known as Macrophage Inflammatory Protein-3beta, MIP-3b, and EBI1 ligand chemokine, ELC) directs chemotaxis of dendritic cells and certain B- and T-lymphocytes, but not monocytes or granulocytes. It is constitutively expressed in thymus and lymph nodes and binds specifically to target cells expressing the receptor CCR7. As a homeostatic chemokine, its primary physiological role is thought to be in the normal recirculation and homing of lymphocytes. However, CCL19 can also be proinflammatory and is implicated in post-HIV infection responses.

• CAS Number:

  9000-83-3