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Sincalide

CAT: 0804-HY-P0093-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P0093-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Sincalide (Cholecystokinin octapeptide, CCK-8) is a rapid-acting amino acid polypeptide hormone analogue of cholecystokinin (CCK) for intravenous use in postevacuation cholecystography. Sincalide is a major bioactive segment of CCK that retains most of the biological activities of CCK. Sincalide can promote gallbladder contraction by injection and helps diagnose gallbladder and pancreas disorders. Sincalide can increase bile secretion, cause the gallbladder to contract and relax the sphincter of Oddi, resulting in bile drainage into the duodenum. Sincalide is a major bioactive segment of CCK that retains most of the biological activities of CCK[1][2][3].
CAS Number
25126-32-3
Product Name Alternative
Cholecystokinin octapeptide; CCK-8; SQ19844
UNSPSC
12352209
Hazard Statement
H302, H312, H332
Target
Akt; Apoptosis; Cholecystokinin Receptor; PI3K
Type
Peptides
Related Pathways
Apoptosis; GPCR/G Protein; Neuronal Signaling; PI3K/Akt/mTOR
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/Sincalide.html
Purity
99.00
Solubility
DMF : 50 mg/mL (ultrasonic) |DMSO : 25 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic; adjust pH to 11 with NH3·H2O)
Smiles
NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CNC2=C1C=CC=C2)NC(CNC([C@@H](NC([C@H](CC3=CC=C(C=C3)OS(=O)(O)=O)NC([C@H](CC(O)=O)N)=O)=O)CCSC)=O)=O)=O)CCSC)=O)CC(O)=O)=O)CC4=CC=CC=C4)=O
Molecular Formula
C49H62N10O16S3
Molecular Weight
1143.27
Precautions
H302, H312, H332
References & Citations
[1]Maher KA et al. Kinevac (sincalide for injection) /Squibb Diagnostics. Gastroenterol Nurs. 1991 Oct;14 (2) :98-100.|[2]Ziessman HA. Sincalide: A Review of Clinical Utility, Proper Infusion Methodology, and Alternative Cholecystogogues. J Nucl Med Technol. 2019 Sep;47 (3) :210-212.|[3]Can Wang, et al. Cholecystokinin octapeptide reduces myocardial fibrosis and improves cardiac remodeling in post myocardial infarction rats. Int J Biochem Cell Biol. 2020 Aug;125:105793.|[4]Can Wang, et al. Protective effect of cholecystokinin octapeptide on angiotensin II-induced apoptosis in H9c2 cardiomyoblast cells. J Cell Biochem. 2020 Jul;121 (7) :3560-3569.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Scientific Category
Peptides
Clinical Information
Launched

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