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Eliprodil

CAT: 0804-HY-12881-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12881-01Size:5 mg
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Description
Eliprodil (SL-820715) is a non-competitive NR2B-NMDA receptor antagonist (IC50=1 uM), less potent for NR2A- and NR2C-containing receptors (IC50> 100 uM) . IC50 value: Target: NR2B-NMDA antagonist Human N-type Ca2+ channel currents were inhibited by ifenprodil and eliprodil with IC50 values of 50 microM and 10 microM respectively whereas P-type Ca2+ channel currents were inhibited reversibly by ifenprodil and eliprodil with approximate IC50 values of 60 microM and 9 microM respectively. eliprodil (1 microm) produced a moderate reverse rate-dependent prolongation of the action potential duration (7.4+/-1.5, 8.9+/-2.1 and 9.9+/-1.8% at cycle lengths of 300, 1000 and 5000 ms, respectively; n=9) .
CAS Number
119431-25-3
Product Name Alternative
SL-820715
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Eliprodil.html
Purity
99.65
Solubility
DMSO : 14.29 mg/mL (ultrasonic)
Smiles
ClC(C=C1)=CC=C1C(O)CN(CC2)CCC2CC3=CC=C(F)C=C3
Molecular Formula
C20H23ClFNO
Molecular Weight
347.85
Precautions
H302, H315, H319, H335
References & Citations
[1]Bath CP, et al. The effects of ifenprodil and eliprodil on voltage-dependent Ca2+ channels and in gerbil global cerebral ischaemia. Eur J Pharmacol. 1996 Mar 28;299 (1-3) :103-12.|[2]Lengyel C, et al. Effect of a neuroprotective drug, eliprodil on cardiac repolarisation: importance of the decreased repolarisation reserve in the development of proarrhythmic risk. Br J Pharmacol. 2004 Sep;143 (1) :152-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
NMDA Receptor

Alternative Products

CatalogName
B6968-5Eliprodil
A12946-10Eliprodil 10mg
A12946-50Eliprodil 50mg
A12946-5Eliprodil 5mg
A12946-200Eliprodil 200mg
A12946-100Eliprodil 100mg
A12946-25Eliprodil 25mg
S6731-5mgEliprodil (SL-820715)
MBS131239-01Eliprodil, SL-820715

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