Compstatin

• Description:

  Compstatin, a 13-residue cyclic peptide, is a potent inhibitor of the complement system C3 with species specificity. Compstatin binds to baboon C3 and is resistant to proteolytic cleavage in baboon blood (similar to humans) . Compstatin inhibits only the activation of primates’ complement system. Compstatin exhibits IC50 values of 63 μM and 12 μM for classical and alterative complement pathway, respectively[1][2][3][4].

• UNSPSC:

  12352209

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Complement System

• Type:

  Peptides

• Related Pathways:

  Immunology/Inflammation

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/Compstatin.html

• Purity:

  99.58

• Solubility:

  H2O : 100 mg/mL (ultrasonic)

• Smiles:

  O=C([C@@H](N)[C@H](CC)C)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H]1CCCNC(N)=N)=O)CC2=CNC=N2)=O)CC3=CNC=N3)=O)=O)CC4=CNC5=CC=CC=C45)=O)CC(O)=O)=O)CCC(N)=O)=O)C(C)C)=O)C(C)C)=O)CSSC[C@H](NC1=O)C(N[C@H](C(N)=O)[C@@H](C)O)=O

• Molecular Formula:

  C66H99N23O17S2

• Molecular Weight:

  1550.77

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Soulika AM, et al. Inhibition of heparin/protamine complex-induced complement activation by Compstatin in baboons. Clin Immunol. 2000 Sep;96 (3) :212-21.|[2]Fiane AE, et al. Compstatin, a peptide inhibitor of C3, prolongs survival of ex vivo perfused pig xenografts. Xenotransplantation. 1999 Feb;6 (1) :52-65.|[3]Bert J C Janssen, et al. Structure of compstatin in complex with complement component C3c reveals a new mechanism of complement inhibition. J Biol Chem. 2007 Oct 5;282 (40) :29241-7.|[4]A Sahu, et al. Inhibition of human complement by a C3-binding peptide isolated from a phage-displayed random peptide library. J Immunol. 1996 Jul 15;157 (2) :884-91.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• CAS Number:

  [206645-99-0]