Puerarin

• Description:

  Puerarin is an isoflavone extracted from Pueraria root and is a 5-HT2C receptor antagonist. Puerarin inhibits the dorsal motor nucleus of the vagus (DMV) -vagus nerve pathway, which in turn leads to decreased fat absorption[1][2][3][4][5].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  5-HT Receptor

• Type:

  Natural Products

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology; Cancer; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/Puerarin.html

• Purity:

  98.92

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O=C1C (C2=CC=C (O) C=C2) =COC3=C ([C@H]4[C@@H] ([C@H] ([C@@H] ([C@@H] (CO) O4) O) O) O) C (O) =CC=C13

• Molecular Formula:

  C21H20O9

• Molecular Weight:

  416.38

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Hu W, et al. Puerarin inhibits iNOS, COX-2 and CRP expression via suppression of NF-κB activation in LPS-induced RAW264.7 macrophage cells. Pharmacol Rep. 2011;63 (3) :781-9.|[2]Zhang H, et al. Puerarin: a novel antagonist to inward rectifier potassium channel (IK1) . Mol Cell Biochem. 2011 Jun;352 (1-2) :117-23.|[3]Zhao L, et al. Protective Effects of Genistein and Puerarin against Chronic Alcohol-Induced Liver Injury in Mice via Antioxidant, Anti-inflammatory, and Anti-apoptotic Mechanisms. J Agric Food Chem. 2016 Sep 28;64 (38) :7291-7.|[4]Pan X, et al. Effect of Puerarin on Expression of ICAM-1 and TNF-α in Kidneys of Diabetic Rats. Med Sci Monit. 2015 Jul 23;21:2134-40.|[5]Lyu, et al. "A brain-to-gut signal controls intestinal fat absorption." Nature (2024) : 1-8.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  Launched

• Isoform:

  5-HT2 Receptor; α-1 microglobulin

• CAS Number:

  3681-99-0