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Puerarin

CAT: 0804-HY-N0145-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N0145-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Puerarin is an isoflavone extracted from Pueraria root and is a 5-HT2C receptor antagonist. Puerarin inhibits the dorsal motor nucleus of the vagus (DMV) -vagus nerve pathway, which in turn leads to decreased fat absorption[1][2][3][4][5].
CAS Number
[3681-99-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
5-HT Receptor
Type
Natural Products
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Puerarin.html
Purity
98.92
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1C(C2=CC=C(O)C=C2)=COC3=C([C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O)C(O)=CC=C13
Molecular Formula
C21H20O9
Molecular Weight
416.38
Precautions
H302, H315, H319, H335
References & Citations
[1]Hu W, et al. Puerarin inhibits iNOS, COX-2 and CRP expression via suppression of NF-κB activation in LPS-induced RAW264.7 macrophage cells. Pharmacol Rep. 2011;63 (3) :781-9.|[2]Zhang H, et al. Puerarin: a novel antagonist to inward rectifier potassium channel (IK1) . Mol Cell Biochem. 2011 Jun;352 (1-2) :117-23.|[3]Zhao L, et al. Protective Effects of Genistein and Puerarin against Chronic Alcohol-Induced Liver Injury in Mice via Antioxidant, Anti-inflammatory, and Anti-apoptotic Mechanisms. J Agric Food Chem. 2016 Sep 28;64 (38) :7291-7.|[4]Pan X, et al. Effect of Puerarin on Expression of ICAM-1 and TNF-α in Kidneys of Diabetic Rats. Med Sci Monit. 2015 Jul 23;21:2134-40.|[5]Lyu, et al. "A brain-to-gut signal controls intestinal fat absorption." Nature (2024) : 1-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
5-HT2 Receptor; α-1 microglobulin

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