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Recombinant Human ROR1 Protein, C-hFc

CAT: 1676-PR17117Size: 100μg/1mgDry Ice: NoHazardous: No
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CAT#:1676-PR17117Size:100μg/1mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ROR1 (receptor tyrosine kinase-like orphan receptor 1) is a RTK-like protein with no known ligand. It is highly expressed in early development, lower in most adult tissues, and upregulated in some cancers. The extracellular region binds ligands (if any) and a transmembrane domain anchors the protein; the intracellular region has a kinase-like domain. Its catalytic activity is debated but it can regulate proliferation, migration, and survival through downstream signaling, playing roles in immune and developmental pathways and attracting cancer therapy interest. ROR1 engages non-canonical Wnt signaling and downstream PI3K/AKT and MAPK pathways. Interactions with ligands like WNT5A or other membrane proteins activate Rho GTPases and Vav/Rac1, promoting cytoskeletal changes and migration, and can influence cell cycle and survival signals. Despite debated kinase activity, substrate selectivity or co-regulator interactions can modulate AKT and ERK signaling, affecting proliferation, drug resistance, and stem-like properties. Effects are context-dependent, varying by cell type and environment.
Product Name Alternative
ROR1, NTRKR1
Accession Number
Q01973-1
Tag
C-hFc
Source
HEK293 Cells
Endotoxin
<1 EU/μg as determined by LAL test.
Purity
>95% as determined by SDS-PAGE.
Form
Liquid
Molecular Weight
67.9 kDa
Shipping Conditions
The product is shipped on dry ice. Upon receipt, store it immediately at the temperature listed below.
Storage Conditions
Store at ≤-70°C. Please minimize freeze-thaw cycles and use a manual defrost freezer.
Protein Length
Gln30-Glu403
Formulation
Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4.
Species
Human

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