Recombinant Human ROR2 Protein, C-His

ROR2 protein is a receptor tyrosine kinase that belongs to the ROR family (related to the tropomyosin receptor kinase family) . It is encoded by the ROR2 gene and is a protein associated with skeletal development and tissue morphogenesis. ROR2 protein was initially identified in fetal tissues and later detected in various cell types including osteoblasts, chondrocytes, and multiple cancer cells. ROR2 protein regulates cell polarity, migration, and differentiation by binding to its ligand Wnt5a and activating non-canonical Wnt signaling pathways, such as the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. Osteoblasts and chondrocytes are important types of mesenchymal cells with critical functions in bone formation, cartilage development, and tissue patterning, making them central members of the skeletal system. Research indicates that ROR2 protein plays a significant role in promoting embryonic morphogenesis, enhancing cell movement, and modulating tissue organization. Additionally, the expression of ROR2 protein is associated with skeletal disorders such as Robinow syndrome, as well as tumor progression, metastasis, and immune modulation in various cancers, making it a potential target for regenerative medicine and cancer immunotherapy.

NTRKR2

A1L4F5-1

C-His

HEK293 Cells

<1 EU/μg as determined by LAL test.

>95% as determined by SDS-PAGE.

Liquid

42.2 kDa

The product is shipped on dry ice. Upon receipt, store it immediately at the temperature listed below.

Store at ≤-70°C. Please minimize freeze-thaw cycles and use a manual defrost freezer.

Glu34-Gly403

Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4.