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DN401

CAT: 0804-HY-115781-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-115781-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DN401 is a potent TRAP1 inhibitor with an IC50 of 79 nM. DN401 shows a weak inhibition of Hsp90 (IC50 of 698 nM) . DN401 inactivates mitochondrial TRAP1 and has potent anticancer activities[1].
CAS Number
2135749-60-7
Product Name Alternative
Panvotinib-401; Pan-401
UNSPSC
12352005
Target
HSP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dn401.html
Purity
99.0
Solubility
DMSO : 17.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
NC1=NC(Cl)=C2C(N(N=C2)CC3=C(C=C4OCOC4=C3)Br)=N1
Molecular Formula
C13H9BrClN5O2
Molecular Weight
382.60
References & Citations
[1]Hye-Kyung Park, et al. Paralog Specificity Determines Subcellular Distribution, Action Mechanism, and Anticancer Activity of TRAP1 Inhibitors. J Med Chem. 2017 Sep 14;60 (17) :7569-7578.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HSP90

Alternative Products

CatalogName
T27193-01DN401

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