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5-Hydroxydecanoate (sodium)

CAT: 0804-HY-136615-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-136615-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
5-Hydroxydecanoate sodium is a selective ATP-sensitive K+ (KATP) channel blocker (IC50 of ~30 μM) . 5-Hydroxydecanoate sodium is a substrate for mitochondrial outer membrane acyl-CoA synthetase and has antioxidant activity[1][2].
CAS Number
71186-53-3
UNSPSC
12352211
Hazard Statement
H315, H319
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/5-hydroxydecanoate-sodium.html
Concentration
10mM
Purity
99.96
Solubility
DMSO : 12.5 mg/mL (ultrasonic) |H2O : 10 mg/mL (ultrasonic)
Smiles
CCCCCC(O)CCCC(O[Na])=O
Molecular Formula
C10H19NaO3
Molecular Weight
210.25
Precautions
H315, H319
References & Citations
[1]Congna Zi, et al. Penehyclidine hydrochloride protects against anoxia/reoxygenation injury in cardiomyocytes through ATP-sensitive potassium channels, and the Akt/GSK-3β and Akt/mTOR signaling pathways. Cell Biol Int. 2020 Jun;44 (6) :1353-1362.|[2]Xiantao Li, et al. 5-Hydroxydecanoate and coenzyme A are inhibitors of native sarcolemmal KATP channels in inside-out patches. Biochim Biophys Acta. 2010 Mar;1800 (3) :385-91.|[3]M G Marina Prendes, et al. Effects of 5-hydroxydecanoate and ischemic preconditioning on the ischemic-reperfused heart of fed and fasted rats. J Physiol Biochem. 2005 Sep;61 (3) :447-56.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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