(1S,2S)-ML-SI3

(1S,2S)-ML-SI3

• CAS Number: 2563870-87-9
• UNSPSC Description: (1S,2S)-ML-SI3 is a trans-isomer of ML-SI3 that targets all three isoforms of TRPML. (1S,2S)-ML-SI3 is an activator of TRPML2 and TRPML3 (EC50=2.7 μM/10.8 μM) and a potent inhibitor of TRPML1 (IC50=5.9 μM)[1].
• Target Antigen: TRP Channel
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel;Neuronal Signaling
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/1s-2s-ml-si3.html
• Smiles: COC1=CC=CC=C1N2CCN([C@H]3CCCC[C@@H]3NS(C4=CC=CC=C4)(=O)=O)CC2
• Molecular Weight: 429.58
• References & Citations: [1]Leser C, et al. Chemical and pharmacological characterization of the TRPML calcium channel blockers ML-SI1 and ML-SI3. Eur J Med Chem. 2021 Jan 15;210:112966.
• Shipping Conditions: Room Temperature