Prostratin

• Description :

  Prostratin, a natural terpenoid compound, is a PKC activator, with a Ki of 12.5 nM and shows inhibitory effect on HIV-1.

• UNSPSC :

  12352211

• Target :

  HIV; PKC

• Type :

  Natural Products

• Related Pathways :

  Anti-infection; Epigenetics; TGF-beta/Smad

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Cancer; Infection

• Assay Protocol :

  https://www.medchemexpress.com/prostratin.html

• Purity :

  99.80

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  CC(O[C@@]12[C@@]([C@@]3([H])[C@]([C@@H](C2)C)([C@@]4([H])[C@](CC(CO)=C3)(C(C(C)=C4)=O)O)O)([H])C1(C)C)=O

• Molecular Formula :

  C22H30O6

• Molecular Weight :

  390.47

• References & Citations :

  [1]Gustafson KR, et al. A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1. J Med Chem. 1992 May 29;35 (11) :1978-86.|[2]Shen X, et al. The protein kinase C agonist prostratin induces differentiation of human myeloid leukemia cells and enhances cellular differentiation by chemotherapeutic agents. Cancer Lett. 2015 Jan 28;356 (2 Pt B) :686-96.|[3]Wang H, et al. Protein kinase D3 is essential for prostratin-activated transcription of integrated HIV-1 provirus promoter via NF-κB signaling pathway. Biomed Res Int. 2014;2014:968027.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  PKC

• CAS Number :

  [60857-08-1]