Cromakalim

• Description :

  Cromakalim is a potassium channel opener. Cromakalim can be used as a bronchodilator in asthma. Cromakalim inhibits the spontaneous tone of human isolated bronchi in a concentration-related manner being nearly as effective as isoprenaline or theophylline[1].

• Product Name Alternative :

  BRL 34915

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319

• Target :

  Potassium Channel

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/cromakalim.html

• Purity :

  99.43

• Solubility :

  DMSO : 66.67 mg/mL (ultrasonic)

• Smiles :

  O[C@@H]1[C@@H](N2C(CCC2)=O)C3=CC(C#N)=CC=C3OC1(C)C

• Molecular Formula :

  C16H18N2O3

• Molecular Weight :

  286.33

• Precautions :

  H302, H315, H319

• References & Citations :

  [1]Cortijo J, et al. The relaxant effects of cromakalim (BRL 34915) on human isolated airway smooth muscle. Naunyn Schmiedebergs Arch Pharmacol. 1992;346 (4) :462-468.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [94470-67-4]