Cromakalim

• Description:

  Cromakalim is a potassium channel opener. Cromakalim can be used as a bronchodilator in asthma. Cromakalim inhibits the spontaneous tone of human isolated bronchi in a concentration-related manner being nearly as effective as isoprenaline or theophylline[1].

• Product Name Alternative:

  BRL 34915

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319

• Target:

  Potassium Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/cromakalim.html

• Purity:

  99.43

• Solubility:

  DMSO : 66.67 mg/mL (ultrasonic)

• Smiles:

  O[C@@H]1[C@@H] (N2C (CCC2) =O) C3=CC (C#N) =CC=C3OC1 (C) C

• Molecular Formula:

  C16H18N2O3

• Molecular Weight:

  286.33

• Precautions:

  H302, H315, H319

• References & Citations:

  [1]Cortijo J, et al. The relaxant effects of cromakalim (BRL 34915) on human isolated airway smooth muscle. Naunyn Schmiedebergs Arch Pharmacol. 1992;346 (4) :462-468.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  94470-67-4