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(-) -Syringaresinol

CAT: 0804-HY-126066-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-126066-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(-) -Syringaresinol is an orally active isomer of syringaresinol found in Annona Montana. (-) -Syringaresinol exhibits antioxidant, anti-inflammatory, and anticancer activities. (-) -Syringaresinol can alleviate ulcerative colitis via the PI3K-Akt/MAPK/Wnt signaling pathway. (-) -Syringaresinol inhibits HL-60 cell proliferation by arresting the G1 phase and inducing apoptosis. (-) -Syringaresinol inhibits LPS (HY-D1056) -induced microglial activation by downregulating the NF-κB p65 signaling pathway and its interaction with ERβ, exerting anti-neuroinflammatory effects[1][2][3].
CAS Number
6216-81-5
UNSPSC
12352005
Target
Akt; Apoptosis; Bcl-2 Family; CD20; CDK; COX; Drug Isomer; GSK-3; IFNAR; Interleukin Related; NF-κB; NO Synthase; p38 MAPK; TNF Receptor
Type
Natural Products
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; MAPK/ERK Pathway; NF-κB; Others; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/minus-syringaresinol.html
Purity
99.93
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=C(OC)C=C([C@@H]2OC[C@]3([H])[C@@]2([H])CO[C@H]3C4=CC(OC)=C(O)C(OC)=C4)C=C1OC
Molecular Formula
C22H26O8
Molecular Weight
418.44
References & Citations
[1]Liu Y, et al. (-) -Syringaresinol attenuates ulcerative colitis by improving intestinal epithelial barrier function and inhibiting inflammatory responses. Phytomedicine. 2024 Feb;124:155292. |[2]Park BY, et al. (-) -Syringaresinol inhibits proliferation of human promyelocytic HL-60 leukemia cells via G1 arrest and apoptosis. Int Immunopharmacol. 2008 Jul;8 (7) :967-73. |[3]Zhang L, et al. (-) -Syringaresinol suppressed LPS-induced microglia activation via downregulation of NF-κB p65 signaling and interaction with ERβ. Int Immunopharmacol. 2021 Oct;99:107986.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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