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Recombinant Protein L

CAT: 1676-PR02452Size: 10mg/100mg/1gDry Ice: NoHazardous: No
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CAT#:1676-PR02452Size:10mg/100mg/1g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Protein L was first isolated from the surface of bacterial species Peptostreptoccus magnus and was found to bind Ig through L chain interaction, from which the name was suggested. Different from protein A and protein G, protein L binds predominantly to kappa light chains, without interfering with the antigen-binding site. Among the four major VL subgroups of human κ chains, κI, κIII, and κIV, but not κII, light chains bind to protein L and that this interaction involves exclusively the VL portion of the molecule. Further, this interaction is conformationally dependent and requires the complete VL domain. Since the interaction between Protein L and Ig is with the light chain, it will bind to Ig of all classes. Therefore, it possesses the potential of being a universal Ig ligand. The unique ability of protein L to bind to the kappa light chains of antibodies makes it valuable in detection and purification of antibodies and antibody fragments that contain kappa light chains but not the Fc region, such as antigen-binding VL domains and Fv fragments prepared from monoclonal antibodies or produced in recombinant DNA systems. The isolation of mouse IgG1-class antibodies would be best performed with protein L.
Accession Number
Q51912
Tag
Tag free
Source
E.coli
Endotoxin
<1 EU/μg as determined by LAL test.
Purity
>95% as determined by reducing SDS-PAGE.
Form
Liquid
Molecular Weight
33.7 KDa
Shipping Conditions
The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.
Storage Conditions
Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles and use a manual defrost freezer.
Protein Length
Val95-Glu398
Formulation
Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

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