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Recombinant Human MetAP1 Protein

CAT: 1676-PR02405Size: 10μg/50μg/500μg/1mgDry Ice: NoHazardous: No
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CAT#:1676-PR02405Size:10μg/50μg/500μg/1mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Methionine Aminopeptidase 1 is a member of the M24 family of metalloproteases. METAP1 plays an important role in G (2) /M phase regulation of the cell cycle and may serve as a promising target for the discovery and development of new anticancer agents. METAP1 and METAP2 have different substrate specificity due to the differences in both size and shape of the active sites. The proteolytic removal of N-terminal methionine from nascent peptides is catalyzed by a family of enzymes known as methionine aminopeptidases (MetAPs) and is essential for cell growth. Inhibition of METAPs provides a novel strategy in developing anti-cancer drugs.
Product Name Alternative
Methionine aminopeptidase 1; MAP 1; MetAP 1; Peptidase M 1; METAP1
Accession Number
P53582
Tag
Tag free
Source
E.coli
Endotoxin
<1 EU/μg as determined by LAL test.
Purity
>95% as determined by reducing SDS-PAGE.
Form
Liquid
Molecular Weight
43.2 KDa
Shipping Conditions
The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.
Storage Conditions
Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles and use a manual defrost freezer.
Protein Length
Met1-Phe386
Formulation
Supplied as a 0.2 μm filtered solution of 20 mM Glycine, 10% Sucrose, 10% Glycerol, 0.02% Tween80, pH3.5.
Species
Human

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