RegisterLogin

Crovalimab

CAT: 804-HY-P99965-01Size: 1 mgDry Ice: YesHazardous: No
1 mgSelected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Crovalimab (SKY59; RO7112689) is a novel humanized antibody against C5 in a pH-dependent manner with KDs of 15.2 nM and 16.8 μM at pH 7.4 and 5.8, respectively. Crovalimab binds human FcRn with great affinity (KD: 17 μM at pH 6.0) . Crovalimab can block cleavage of C5 by the C5 convertase and inhibite the activity of a C5 variant (p.Arg885His) . Crovalimab inhibits C5b-9 formation significantly in all three complement pathways, the classical pathway (CP), lectin pathway (LP), and alternative pathway (AP) . Crovalimab has the potential for paroxysmal nocturnal hemoglobinuria (PNH) and complement-mediated diseases research[1][2].
CAS Number
[1917321-26-6]
Product Name Alternative
SKY59; RO7112689; RG-6107
UNSPSC
12352203
Target
Complement System
Type
Inhibitory Antibodies
Related Pathways
Immunology/Inflammation
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/crovalimab.html
Purity
99.95
Solubility
10 mM in DMSO
Smiles
[Crovalimab]
Molecular Weight
(145.28 kDa)
References & Citations
[1]Taku Fukuzawa, et al. Long lasting neutralization of C5 by SKY59, a novel recycling antibody, is a potential therapy for complement-mediated diseases. Sci Rep. 2017 Apr 24;7 (1) :1080.|[2]Wioleta M Zelek, et al. Characterizing a pH-switch anti-C5 antibody as a tool for human and mouse complement C5 purification and cross-species inhibition of classical and reactive lysis. Immunology. 2018 Nov;155 (3) :396-403.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Launched

Related Products

CatalogName

Alternative Products

CatalogName
T77190-01Crovalimab
abx831456-01Crovalimab
MBS5819111Crovalimab
E40YR1488Crovalimab
591772Crovalimab (C5)
E55B0503Crovalimab (Reference antibody)
MBS1563308-01Research Grade Crovalimab
KBI1251KRIBIOLISA™ Crovalimab ELISA
HF687056-01Research Grade Crovalimab
DHB90005Research Grade Crovalimab

Popular Products