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Recombinant Human TREM2 Protein, C-mFc

CAT: 1676-PR02481Size: 10μg/50μg/500μg/1mgDry Ice: NoHazardous: No
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CAT#:1676-PR02481Size:10μg/50μg/500μg/1mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
TREM2 is a cell surface receptor of the immunoglobulin superfamily. TREM2 is a type-1 transmembrane protein that shuttles to the plasma membrane where it exerts its cell autonomous biological functions. TREM2 undergoes regulated intramembrane proteolysis (RIP) . TREM2 is preferentially expressed in microglia and is functionally required for migration, cytokine release, phagocytosis, lipid sensing, ApoE binding, shielding of amyloid plaques, and microglia proliferation in the brian. Most of the functionally investigated mutations are located within the Ig-like domain of TREM2.
Product Name Alternative
Triggering receptor expressed on myeloid cells 2; TREM2; Triggering receptor expressed on monocytes 2; TREM-2
Accession Number
Q9NZC2
Tag
C-mFc
Source
HEK293 Cells
Endotoxin
<1 EU/μg as determined by LAL test.
Purity
>95% as determined by reducing SDS-PAGE.
Form
Lyophilized
Reconstitution
Reconstitute the lyophilized protein in sterile water at a concentration of greater than 100 μg/mL.
Molecular Weight
43.8 KDa
Shipping Conditions
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Storage Conditions
Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. Please minimize freeze-thaw cycles and use a manual defrost freezer.
Protein Length
His19-Ser174
Formulation
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Species
Human

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