Balicatib

CAT: 0804-HY-15100-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-15100-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Balicatib (AAE581) is a potent, orally active and selective cathepsin K inhibitor with IC50 values of 22, 61, 48, 2900 nM for cathepsin K, cathepsin B, cathepsin L, cathepsin S, respectively. Balicatib inhibits bone turnover, decreases bone formation rates. Balicatib has the potential for the research of osteoporosis[1][2].

CAS Number

354813-19-7

Product Name Alternative

AAE581

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Cathepsin

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Balicatib.html

Purity

98.25

Solubility

DMSO : 75 mg/mL (ultrasonic)

Smiles

CCCN1CCN(C2=CC=C(C(NC3(C(NCC#N)=O)CCCCC3)=O)C=C2)CC1

Molecular Formula

C23H33N5O2

Molecular Weight

411.54

Precautions

H315, H319, H335

References & Citations

[1]Jerome C, et al. Balicatib, a cathepsin K inhibitor, stimulates periosteal bone formation in monkeys. Osteoporos Int. 2012 Jan;23 (1) :339-49.|[2]Gauthier JY, et al. The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K. Bioorg Med Chem Lett. 2008 Feb 1;18 (3) :923-8.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Isoform

Cathepsin B; Cathepsin K; Cathepsin L; Cathepsin S

Alternative Products

Catalog	Name
MBS576874	Balicatib
A12020-100	Balicatib 100mg
A12020-50	Balicatib 50mg
A12020-2	Balicatib 2mg
A12020-500	Balicatib 500mg

Balicatib

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