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Recombinant Mouse LEP Protein

CAT: 1676-PR00292Size: 10μg/50μg/500μg/1mgDry Ice: NoHazardous: No
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CAT#:1676-PR00292Size:10μg/50μg/500μg/1mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Leptin is a hormone secreted from white adipocytes and plays important role in the regulation of food intake and energy balance. Leptin functions via signaling pathways involving OB-R in hypothalamus. Animal models have revealed the influence of Leptin in reducing body weight and regulating blood glucose level. When mutations are introduced in obese gene, mice with impaired function of leptin are massively obese and in high risk of diabetes. Leptin deficiency reduces metablic rate. Leptin deficient mice are less active and with lower body temperature than normal animals. Human Leptin shares approximately 84% sequence identity with the mouse protein. Human Leptin consists of 167 amino acid residue including a 21 amino acid residue signal sequence and 146 amino acid residue mature protein sequence.
Product Name Alternative
Leptin; Obese Protein; Obesity Factor; LEP; OB; OBS
Accession Number
Q544U0
Tag
Tag free
Source
E.coli
Endotoxin
<1 EU/μg as determined by LAL test.
Purity
>95% as determined by SDS-PAGE.
Form
Lyophilized
Reconstitution
Reconstitute the lyophilized protein in sterile water at a concentration of greater than 100 μg/mL.
Molecular Weight
16.1 KDa
Shipping Conditions
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Storage Conditions
Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. Please minimize freeze-thaw cycles and use a manual defrost freezer.
Protein Length
Val22-Cys167
Formulation
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 300mM NaCl, pH7.5.
Species
Mouse

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