Products for Research Use Only
RegisterLogin

Recombinant Human GDF5 Protein

CAT: 1676-PR00246Size: 10μg/50μg/500μg/1mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:1676-PR00246Size:10μg/50μg/500μg/1mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Growth Differentiation Factor 5 (GDF-5, BMP-14) is a member of the BMP family of TGFβ superfamily proteins. Human GDF-5, -6, and -7 are a defined subgroup of the BMP family. GDF-5 is synthesized as a homodimeric precursor protein consisting of a 354 amino acid (aa) Nterminal proregion and a 120 aa C-terminal mature peptide. Mature human GDF-5 shares 99% aa sequence identity with both mature mouse and rat GDF-5. GDF-5 signaling is mediated by formation of a heterodimeric complex consisting of a type 1 (BMPR-IB) and a type II (BMPR-IIor Activin RII) serine/threonine kinase receptor which results in the phosphorylation and activation of cytosolic Smad proteins (Smad1, 5, and 8) . GDF-5 is involved in multiple developmental processes including limb generation, cartilage development, joint formation, bone morphogenesis, cell survival, and neuritogenesis. Inhibition of GDF-5 expression or alteration of its signaling can facilitate the development of osteoarthritis.
Product Name Alternative
Growth/differentiation factor 5; GDF-5; Bone morphogenetic protein 14; BMP-14; Cartilage-derived morphogenetic protein 1; CDMP-1; Lipopolysaccharide-associated protein 4; LAP-4; LPS-associated protein 4; Radotermin; CDMP1
Accession Number
P43026
Tag
Tag free
Source
E.coli
Endotoxin
<1 EU/μg as determined by LAL test.
Purity
>95% as determined by SDS-PAGE.
Form
Lyophilized
Reconstitution
Reconstitute the lyophilized protein in 4mM HCl at a concentration of greater than 100 μg/mL.
Molecular Weight
13.7 KDa
Shipping Conditions
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Storage Conditions
Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. Please minimize freeze-thaw cycles and use a manual defrost freezer.
Protein Length
Ala382-Arg501
Formulation
Lyophilized from a 0.2 μm filtered solution of 4mM HCl.
Species
Human

Related Products

CatalogName
WP20623-01U-Blot® GDF5 Polyclonal Antibody
PR17260Recombinant Human GDF15 Protein, C-His
PR17331Recombinant Human GDF15 Protein, N-His
PR05444Recombinant Human GDF6 Protein, N-His
PR16900Recombinant Human GDF7 protein, C-His
PR12292Recombinant Human GDF1 Protein, N-His
PR02623Recombinant Human GDF15 Protein, N-Fc
PR06040Recombinant Human GDF2 Protein, N-His
PR06493Recombinant Human GDF15 Protein, N-His
PR03178Recombinant Human GDF9 Protein, N-His

Alternative Products

CatalogName
CRP2713-01Recombinant Human GDF5 Protein
CST 72306SHuman GDF5 Recombinant Protein
OPCD03502-50UGGDF5 Recombinant Protein
P0301-01Recombinant Human GDF5
E51P90585GDF5 protein, Human, Recombinant (His)
MBS9719467-01Human GDF5 Protein
32-1243-25GDF5 His Recombinant Protein
ARP2221-01Recombinant Mouse GDF5 Protein
AP91611Recombinant Human GDF5 Protein, N-His
TP727601GDF 5 (GDF5) Human Recombinant Protein

Popular Products