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UoS12258

CAT: 0804-HY-123904-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-123904-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
UoS12258 is a selective positive allosteric modulator of AMPA receptor. UoS12258 enhances AMPA receptor‐mediated synaptic transmission. UoS12258 improves performance in cognition rat models, including Scopolamine ‐impaired rats and water maze learning and retention in aged rats[1].
CAS Number
875927-64-3
UNSPSC
12352005
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/uos12258.html
Purity
99.86
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
CC(S(=O)(N[C@H]1CC2=C(C=C(C3=CC=C(F)N=C3)C=C2)C1)=O)C
Molecular Formula
C17H19FN2O2S
Molecular Weight
334.41
References & Citations
[1]Ward SE, et al. Pharmacological characterization of N-[ (2S) -5- (6-fluoro-3-pyridinyl) -2, 3-dihydro-1H-inden-2-yl]-2-propanesulfonamide: a novel, clinical AMPA receptor positive allosteric modulator. Br J Pharmacol. 2017 Mar;174 (5) :370-385.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AMPA Receptor

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