2-PMPA

• Description :

  2-PMPA is a potent and selective inhibitor of glutamate carboxypeptidase II (GCPII) with an IC50 of 300 pM.

• CAS Number :

  [173039-10-6]

• Product Name Alternative :

  2- (Phosphonomethyl) pentanedioic acid

• UNSPSC :

  12352211

• Hazard Statement :

  H315, H319

• Target :

  Carboxypeptidase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/2-PMPA.html

• Purity :

  98.0

• Solubility :

  H2O : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(O)C(CP(O)(O)=O)CCC(O)=O

• Molecular Formula :

  C6H11O7P

• Molecular Weight :

  226.12

• Precautions :

  H315, H319

• References & Citations :

  [1]Rais R, et al. Bioanalytical method for evaluating the pharmacokinetics of the GCP-II inhibitor 2-phosphonomethyl pentanedioic acid (2-PMPA) . J Pharm Biomed Anal. 2014 Jan;88:162-9.|[2]Zuo D, et al. Existence of glia mitigated ketamine-induced neurotoxicity in neuron-glia mixed cultures of neonatal rat cortex and the glia-mediated protective effect of 2-PMPA. Neurotoxicology. 2014 Sep;44:218-30.|[3]Baslow MH, et al. 2-PMPA, a NAAG peptidase inhibitor, attenuates magnetic resonance BOLD signals in brain of anesthetized mice: evidence of a link between neuron NAAG release and hyperemia. J Mol Neurosci. 2005;26 (1) :1-15.|[4]Nagel J, et al. Effects of NAAG peptidase inhibitor 2-PMPA in model chronic pain-relation to brain concentration. Neuropharmacology. 2006 Dec;51 (7-8) :1163-71.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, stored under nitrogen, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported