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INCB16562

CAT: 0804-HY-111077Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-111077Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
INCB16562 is an orally active and selective inhibitor against JAK1/2 markedly selective over JAK3. INCB16562 potently inhibits interleukin-6 (IL-6) -induced phosphorylation of STAT3. Additionally, INCB16562 inhibits the proliferation and survival of myeloma cells dependent on IL-6 for growth, as well as the IL-6–induced growth of primary bone marrow-derived plasma cells. INCB16562 antagonizes the growth of myeloma xenografts in mice with antitumor activity. INCB16562 is promising for research of multiple myeloma[1].
CAS Number
933768-63-9
UNSPSC
12352005
Target
JAK; STAT
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/incb16562.html
Smiles
ClC1=CC=CC(Cl)=C1C2=NC3=C(N2)C4=C(C=NC=C4)NC5=C3C=CC=N5
Molecular Formula
C19H11Cl2N5
Molecular Weight
380.23
References & Citations
[1]Li J, et al. INCB16562, a JAK1/2 selective inhibitor, is efficacious against multiple myeloma cells and reverses the protective effects of cytokine and stromal cell support. Neoplasia. 2010 Jan;12 (1) :28-38.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
T68306-01INCB16562

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