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Gemcabene (calcium)

CAT: 0804-HY-109567A-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-109567A-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Gemcabene calcium (PD-72953 calcium), a first-in-class lipid-lowering agent, lowers low-density lipoprotein cholesterol (LDL-C), decreases triglycerides, and raises high-density lipoprotein cholesterol (HDL-C) and lowers pro-inflammatory acute-phase protein, C-reactive protein (CRP), exerting anti-inflammatory activity[1][2][3].
CAS Number
[209789-08-2]
Product Name Alternative
PD-72953 (calcium)
UNSPSC
12352211
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
COVID-19-immunoregulation
Field of Research
Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/gemcabene-calcium.html
Purity
98.0
Solubility
H2O : 10 mg/mL (ultrasonic)
Smiles
O=C([O-])C(C)(C)CCCCOCCCCC(C)(C([O-])=O)C.[Ca+2]
Molecular Formula
C16H28CaO5
Molecular Weight
340.47
References & Citations
[1]Mandema JW, et al. Model-based development of gemcabene, a new lipid-altering agent. AAPS J. 2005 Oct 7;7 (3) :E513-22.|[2]Srivastava RAK, et al. Gemcabene, a First-in-Class Hypolipidemic Small Molecule in Clinical Development, Attenuates Osteoarthritis and Pain in Animal Models of Arthritis and Pain. Front Pharmacol. 2018 May 11;9:471.|[3]Oniciu DC, et al. Gemcabene downregulates inflammatory, lipid-altering and cell-signaling genes in the STAM™ model of NASH. PLoS One. 2018 May 30;13 (5) :e0194568.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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