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AZ13824374

CAT: 0804-HY-136521-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-136521-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AZ13824374 is a potent and selective ATAD2 bromodomain inhibitor (pIC50 of 6.9 in HCT116 cells) . AZ13824374 disrupts chromatin interactions and gene transcription by binding to the acetyl-lysine binding site of the ATAD2 bromodomain. AZ13824374 has anticancer activity against breast cancer[1].
CAS Number
3040082-19-4
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/az13824374.html
Concentration
10mM
Purity
99.22
Solubility
DMSO : ≥ 200 mg/mL
Smiles
O=C1N[C@H](C(C)C)[C@H]2C3=CC=CC=C3C[C@@H]1N2C(C4=NN5C(C(NC6CCN(CC(C)(F)C)CC6)=C4)=NN=C5C)=O
Molecular Formula
C30H39FN8O2
Molecular Weight
562.68
References & Citations
[1]Winter-Holt JJ, et al. Discovery of a Potent and Selective ATAD2 Bromodomain Inhibitor with Antiproliferative Activity in Breast Cancer Models. J Med Chem. 2022 Feb 24;65 (4) :3306-3331.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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