Abaloparatide

• Description:

  Abaloparatide (BA 058) is a parathyroid hormone receptor 1 (PTHR1) analog. Abaloparatide also is a selective PTHR1 activator. Abaloparatide enhances Gs/cAMP signaling and β-arrestin recruitment. Abaloparatide enhances bone formation and cortical structure in mice. Abaloparatide has the potential for the research of osteoporosis[1][2].

• Product Name Alternative:

  BA 058; BIM 44058

• UNSPSC:

  12352209

• Target:

  Arrestin; PTHR

• Type:

  Peptides

• Related Pathways:

  GPCR/G Protein

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/abaloparatide.html

• Purity:

  99.91

• Solubility:

  DMSO : 25 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL

• Smiles:

  O=C (N[C@@H] (C (C) C) C (N[C@@H] (CO) C (N[C@@H] (CCC (O) =O) C (N[C@@H] (CC1=CNC=N1) C (N[C@@H] (CCC (N) =O) C (N[C@@H] (CC (C) C) C (N[C@@H] (CC (C) C) C (N[C@@H] (CC2=CNC=N2) C (N[C@@H] (CC (O) =O) C (N[C@@H] (CCCCN) C (NCC (N[C@@H] (CCCCN) C (N[C@@H] (CO) C (N[C@@H] ([C@@H] (C) CC) C (N[C@@H] (CCC (N) =O) C (N[C@@H] (CC (O) =O) C (N[C@@H] (CC (C) C) C (N[C@@H] (CCCNC (N) =N) C (N[C@@H] (CCCNC (N) =N) C (N[C@@H] (CCCNC (N) =N) C (N[C@@H] (CCC (O) =O) C (N[C@@H] (CC (C) C) C (N[C@@H] (CC (C) C) C (N[C@@H] (CCC (O) =O) C (N[C@@H] (CCCCN) C (N[C@@H] (CC (C) C) C (N[C@@H] (CC (C) C) C (NC (C) (C) C (N[C@@H] (CCCCN) C (N[C@@H] (CC (C) C) C (N[C@@H] (CC3=CNC=N3) C (N[C@@H] ([C@H] (O) C) C (N[C@@H] (C) C (N) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) [C@H] (C) N

• Molecular Formula:

  C174H300N56O49

• Molecular Weight:

  3960.59

• References & Citations:

  [1]Sahbani K, et al. Abaloparatide exhibits greater osteoanabolic response and higher cAMP stimulation and β-arrestin recruitment than teriparatide. Physiol Rep. 2019 Oct;7 (19) :e14225.|[2]Varela A, et al. One Year of Abaloparatide, a Selective Activator of the PTH1 Receptor, Increased Bone Formation and Bone Mass in Osteopenic Ovariectomized Rats Without Increasing Bone Resorption. J Bone Miner Res. 2017 Jan;32 (1) :24-33.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Peptides

• Clinical Information:

  Launched

• Citation 01:

  BMC Oral Health. 2025 Sep 29;25 (1) :1492.|Proc Natl Acad Sci U S A. 2021 Nov 9;118 (45) :e2107363118.

• CAS Number:

  247062-33-5