PND-1186

• Background :

  FAK (Focal Adhesion Kinase; PTK2) is a protein kinase involving cell adhesion and migration. FAK plays an important role in many cancers including pancreatic tumors. In addition, recent studies showed FAK inhibitor enables an anti-tumor immune response, resulting in tumor destruction in a mouse model.

• Description :

  PND-1186 (VS-4718) is a potent, highly-specific and reversible inhibitor of FAK with an IC50of 1.5 nM. PND-1186 selectively promotes tumor cell apoptosis.1

• Purity :

  ≥ 90%

• Format :

  Solid.

• Solubility :

  Soluble in DMSO up to 34 mg/mL.

• Molecular Formula :

  C25H26F3N5O3

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  Powder-20°C3 years4°C2 yearsIn solvent-80°C2 years-20°C1 year

• Calculated Molecular Weight :

  501.50 Da

• CAS Number :

  1061353-68-1