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PND-1186

CAT: 0421-82815-1Size: 10 mM x 1 mL DMSODry Ice: NoHazardous: No
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CAT#:0421-82815-1Size:10 mM x 1 mL DMSO
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
FAK (Focal Adhesion Kinase; PTK2) is a protein kinase involving cell adhesion and migration. FAK plays an important role in many cancers including pancreatic tumors. In addition, recent studies showed FAK inhibitor enables an anti-tumor immune response, resulting in tumor destruction in a mouse model.
Description
PND-1186 (VS-4718) is a potent, highly-specific and reversible inhibitor of FAK with an IC50of 1.5 nM. PND-1186 selectively promotes tumor cell apoptosis.1
CAS Number
1061353-68-1
Purity
≥ 90%
Format
Solid.
Solubility
Soluble in DMSO up to 34 mg/mL.
Molecular Formula
C25H26F3N5O3
Shipping Conditions
Room Temperature
Storage Conditions
Powder-20°C3 years4°C2 yearsIn solvent-80°C2 years-20°C1 year
Calculated Molecular Weight
501.50 Da

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462750-01PND-1186
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A13140-100PND-1186 100mg
A13140-25PND-1186 25mg

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