Products for Research Use Only
RegisterLogin

Vandortuzumab

CAT: 0421-82750-2Size: 5 mgDry Ice: YesHazardous: No
Product image 1
1 / 1
CAT#:0421-82750-2Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
STEAP1 (six transmembrane epithelial antigen of the prostate 1), also called STEAP, belongs to the STEAP family of metalloproteinases, which are involved in iron and copper regulation and other processes. It is a cell surface protein expressed in several types of cancer, most notably prostate cancer where STEAP1 was identified as a cancer specific cell-surface antigen. The upregulation of STEAP1 is linked to promotion of cancer cell proliferation and metastatic transformation and higher STEAP expression levels are correlated with poor survival. The differential expression of STEAP1 between cancer cells and normal tissue makes STEAP1 a promising target for antibody-drug-conjugate (ADC) development. The use of STEAP1 CAR (chimeric antigen receptor) -T cell therapy combined with tumor-localized IL-12 therapy is also under study for the treatment of prostate cancer.
Description
Vandortuzumab is a CHO-expressed humanized antibody targeting STEAP1. Vandortuzumab has a huIgG1 type heavy chain and a huκ type light chain, with a predicted molecular weight (MW) of 148.74 kDa.
Endotoxin
< 1 EU/mg
Purity
≥ 90%
Format
Aqueous buffer solution.
Shipping Conditions
-80°C
Storage Conditions
Store at -80°C for 2 years. Aliquots should be stored at the same temperature after first use to avoid multiple freeze-thaws.
Calculated Molecular Weight
148.87 kDa
Formulation
Supplied as a 0.22 μm filtered solution in NaAC, 0.2 M L-Arginine, pH 5.5.

Alternative Products

CatalogName
HY-P990673-01Vandortuzumab
T9901A-052-01Vandortuzumab vedotin
CBA1081-01Vandortuzumab Biosimilar
A2343-01Vandortuzumab (Anti-STEAP1)
WA3747Research Grade Vandortuzumab
048335STEAP1 (vandortuzumAb) discontinued
592294Vandortuzumab Vedotin (STEAP1)
GTR18412418-01Vandortuzumab vedotin Antibody
E55B0609Vandortuzumab (Reference antibody)
A138816Vandortuzumab Biosimilar (Monoclonal, IgG1)

Popular Products