Doramapimod

• Description :

  Doramapimod is a protein kinase inhibitor with a >330-fold selectivity for p38 MAPK compared with 12 other protein kinases. Doramapimod prevents both the kinetic activity and phosphorylation of p38 MAPK by binding to the ATP pocket as well as to a novel allosteric binding site on p38 MAPK. Doramapimod also blocks proliferation of cells expressing BCR-ABL (T315I), with an IC50 of 2-3 µM.

• Purity :

  98% by TLC NMR

• Format :

  White to off-white solid.

• Solubility :

  Soluble in DMSO (up to 50 mg/mL) or in Ethanol (up to 30 mg/mL)

• Molecular Formula :

  C31H37N5O3

• Shipping Conditions :

  -20°C

• Storage Conditions :

  Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.

• Calculated Molecular Weight :

  527.66 Da

• CAS Number :

  285983-48-4