CD157 (BST1), His-Tag Recombinant

• Background:

  CD157, also known as BST1 (bone marrow stromal cell antigen-1) is a glycosylphosphatidylinositol (GPI) -anchored moleculewith the dual functions of receptor and β-NAD+metabolizing ectoenzyme, of the ADP-ribosyl cyclase family. This protein is expressed in the myeolomonocytic lineage (monocytes, neutrophils and others) and mesenchymal stem cells, mesothelial cells and many others. It plays a role in leukocyte adhesion, migration and diapedesis via its heparin-binding domains. Abnormalities in this protein are implicated in inflammatory disorders, such as RA (rheumatoid arthritis) . A potential therapeutic avenue for disorders where CD157 is implicated is the disruption of its interaction with ECM (extracellular matrix) proteins.

• Description:

  Recombinant human CD157, also known as BST1 (bone marrow stromal cell antigen 1), encompassing amino acids 29-292. This construct contains a C-terminal His-tag (6xHis) . The protein was affinity purified.

• UniProt:

  Q10588

• Tag:

  C-terminal His-Tag

• Applications:

  Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

• Purity:

  ≥ 90%

• Format:

  Aqueous buffer solution.

• Shipping Conditions:

  -80°C

• Storage Conditions:

  At least 6 months at -80°C.

• Calculated Molecular Weight:

  31 kDa + glycans

• Formulation:

  8 mM phosphate, pH 7.4,110 mM NaCl, 2.2 mM KCl, and 20% glycerol

• Glycosylation:

  This protein runs at a higher MW by SDS-PAGE due to glycosylation.