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IL-23, His-Tag Recombinant

CAT: 0421-102096-1Size: 5 µgDry Ice: NoHazardous: No
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CAT#:0421-102096-1Size:5 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
IL-23 (interleukin 23) is a cytokine involved in inflammation. It is composed of two subunits, IL-12-B (or IL-12p40) and IL-23A (or IL-23p19) and binds to the IL-23 receptor. It supports Th17 T cell maintenance, expansion and cytokine release, NK cell IFNγ (interferon γ) secretion and increased ADCC (antibody-dependent cellular cytotoxicity) and CD4+T cell proliferation. Il-23 is produced and secreted by activated dendritic cells, macrophages, B cells and γδ T cells. Excessive production of this cytokine can lead to autoimmune disorders, such as psoriasis, and even cancer. Ustekinumab (sold under the brand name STELARA®) and guselkumab (sold under the brand name Tremfya®) are two commercial monoclonal antibodies targeting IL-23, designed for the treatment of Crohn’s disease, ulcerative colitis, plaque and arthritic psoriasis. The success of these two drugs indicates the relevance of this cytokine in human health and disease, making it a valuable therapeutic target.
Description
Recombinant human IL-23 (interleukin 23), encompassing amino acids 20-189. The construct includes a C-terminal His-tag. This protein was affinity purified.
UniProt
Q9NPF7
Tag
C-terminal His-tag
Applications
Useful for cell culture-based assays.
Endotoxin
Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1 EU/µg) .
Purity
> 95%, as determined by SDS-PAGE and HPLC
Format
Recombinant IL-23A was lyophilized from 0.2 µm filtered PBS solution pH 7.4
Reconstitution
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Storage Conditions
The lyophilized protein is stable for at least 2 years from date of receipt at -20°C.
Calculated Molecular Weight
Due to glycosylation migrates as an approximately 28 kDa protein on SDS-PAGE

UniProtKB · Q9NPF7

Interleukin-23 subunit alpha

IL23A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9NPF7
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IL23A
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
IL-23 subunit alpha, IL-23-A
EC number
—
Processing
Precursor
Secondary accessions
Q6NZ80, Q6NZ82, Q9H2A5
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

Antiviral defenseImmunityInflammatory responseInnate immunityTissue remodeling

Molecular function

Cytokine

PTM

Disulfide bond

Cellular component

Secreted

Domain

Signal

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