RegisterLogin

A-1155463

CAT: 0421-82803-4Size: 50 mgDry Ice: NoHazardous: No
CAT#:0421-82803-4Size:50 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
BCL-XL (B-cell lymphoma-extra large), also called BCL2L1, is a member of the BCL-2 family of proteins and is involved in regulating apoptosis. BCL-XL is part of the group of BCL-2 proteins considered pro-survival proteins, as when bound to their effector proteins they inhibit apoptosis.  BCL-XL plays a role in the permeability of mitochondrial membrane, allowing the release of cytochrome C. In addition to its role in apoptosis, it is also involved in neural growth, synaptic plasticity, and neuroprotection. As their name indicates, they are found at abnormal levels in B-cell lymphoma and may contribute to the progression of the disease. BCL-XL overexpression is found in about 80% of lymphomas, and it is thus an attractive target in cancer therapy. Recently it has been identified as being a player in autoimmune disorders and ageing, by controlling the apoptosis rate of immune cells, fibroblasts and other cell types. Several therapeutic approaches have been explored to target BCL-XL, ranging from small inhibitors, such as navitoclax, to PROTACs (proteolysis targeting chimeras) . PROTAC 753B, a PROTAC targeting BCL-XL/BCL2 to VHL (von Hippel-Lindau), has been shown to increase the effects of chemotherapy, while avoiding off-target effect on platelets, as these do not express VHL. Advances in small inhibitors are also ongoing and promise to bring benefit to oncologic patients.
Description
A-1155463 is a highly potent and selective BCL-XL inhibitor with an EC50of 70 nM in Molt-4 cell.1A-1155463 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
1235034-55-5
Purity
≥ 90%
Format
Solid.
Solubility
Soluble in DMSO up to 50 mg/mL.
Molecular Formula
C35H32FN5O4S2
Shipping Conditions
Room Temperature
Storage Conditions
Powder-20°C3 years4°C2 yearsIn solvent-80°C2 years-20°C1 year
Calculated Molecular Weight
669.79 Da

Related Products

CatalogName

Alternative Products

CatalogName
M10940-01A-1155463
440627-01A-1155463 Hydrochloride
A16112-2A-1155463 2mg
A16112-25A-1155463 25mg
C18039A-1155463 Dihydrochloride
A16112-10A-1155463 10mg
A16112-1A-1155463 1mg
A16112-5A-1155463 5mg
A16112-50A-1155463 50mg
A16112-100A-1155463 100mg

Popular Products