PFI-3

• Description:

  PFI-3 is a selective chemical probe for SMARCA bromodomains that inhibits SMARCA2, SMARCA4 and PB1 (5) bromodomains. PFI-3 is a probe that binds avidly to the structurally-similar SMARCA4 bromodomain and PB1 (bromodomain 5) with Kd values of 89 and 48 nM, respectively. PFI-3 displays 30-fold selectivity over other sub-family branches and accelerates FRAP recovery in cells at a concentration of 1 μM.

• Format:

  Solid

• Molecular Formula:

  C19H19N3O2

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  At least 6 months at -20°C.

• Calculated Molecular Weight:

  321.4 Da

• CAS Number:

  1819363-80-8