NI-57

• Description:

  NI-57 is a selective and potent inhibitor of BRPF (Bromodomain and PHD Finger) family of proteins (BRPF1/2/3) . NI-57 shows Kd values of 31,108 and 408 nM, for BRPF1B, 2 and 3, respectively. NI-57 also exhibits >32-fold selectivity for BRPFs over BRD9 and other non-Class IV bromodomains. Inhibits RANKL-induced differentiation of primary murine bone marrow cells and human primary monocytes into osteoclasts.

• Format:

  Solid

• Molecular Formula:

  C19H17N3O4

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  At least 6 months at -20°C.

• Calculated Molecular Weight:

  383.4 Da

• CAS Number:

  1883548-89-7