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M-PEG4-Br

CAT: 0804-HY-130161-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-130161-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
M-PEG4-Br is a cleavable ADC linker used in the synthesis of antibody-drug conjugate (ADC) for Trastuzumab. m-PEG4-Br is placed distally from the monomethyl auristatin E (MMAE) payload to yield an ADC with altered hydrophilicity, antigen binding, and in vitro potency[1]. m-PEG4-Br also can be used as a PROTAC linker that can be used in the synthesis of PROTACs.
CAS Number
110429-45-3
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/m-peg4-br.html
Purity
98.81
Solubility
10 mM in DMSO
Smiles
COCCOCCOCCOCCBr
Molecular Formula
C9H19BrO4
Molecular Weight
271.15
Precautions
H302, H315, H319, H335
References & Citations
[1]Walker JA, et al. Hydrophilic Sequence-Defined Cross-Linkers for Antibody-Drug Conjugates.Bioconjug Chem. 2019 Nov 20;30 (11) :2982-2988.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker; PEG Linkers

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